Making triazoles, the green way

Synthetic 1,2,3-triazoles, with their unusual N,N, bonding arrangements, have become important organic substrates owing to their many possible applications, ranging from industrial uses to a variety of pharmaceutical applications. For example, triazoles are used in the manufacture of dyes and inks, corrosion inhibitors, and polymers. Additionally, triazole-containing molecules have been shown to have anti-allergenic,² anti-bacterial and anti-HIV³ activities, and are under study as drugs for the treatment of osteoarthritis⁴ and obesity.⁵ These heterocycle compounds are particularly interesting for pharmaceutical applications because they are more likely to be water soluble than standard aromatic systems, and are stable under biological conditions.