Chemistry Outreach: Aspirin

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Students undertake the synthesis and analysis of aspirin.

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Aspirin experiment
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16-18 years

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Specification

Northern Ireland
- A/AS level
  - CCEA Chemistry
    - Unit A2 2: Analytical, Transition Metals, Electrochemistry and Organic Nirtrogen Chemistry
      - 5.11 Chemistry in medicine
        5.11.7 recall the synthesis of aspirin from salicylic acid using ethanoic anhydride and reasons for its use as a sodium salt;
        5.11.8 use TLC and GLC MS to identify drugs and their purity (link with Section 5.4);
England
- A/AS level
Scotland
- Higher
  - SQA Chemistry
    - 2. Nature's chemistry
      - (d) Esters, fats and oils
        An ester is a molecule containing an ester link: ─COO─.
- Advanced Higher
  - SQA Chemistry
    - Researching Chemistry
      - Practical skills and techniques
        Melting point
        Candidates should be familiar with determination of melting point and mixed melting point experimental procedures.
        Thin-layer chromatography
        Candidates should be familiar with thin-layer chromatography experimental procedure.
        Recrystallisation
        Candidates should be familiar with recrystallisation experimental procedure.
      - Experiments
        7A. Preparation of aspirin (acetyl salicylic acid).
    - Developing skills for learning, life and work
      - Working with others
        Learning activities provide many opportunities, in all areas of the Course, for learners to work with others. Practical activities and investigations, in particular, offer opportunities for group work, which is an important aspect of chemistry and should…
Wales
- A/AS level
  - WJEC Chemistry
    - Unit 4: ORGANIC CHEMISTRY AND ANALYSIS
      - 4.8 Organic synthesis and analysis
        (b) principles underlying the techniques of manipulation, separation and purification used in organic chemistry
        (g) use of chromatographic data from TLC/paper chromatography, GC and HPLC to find the composition of mixtures
        PRACTICAL: Paper chromatography separation, including two-way separation

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Chemistry Outreach: Aspirin

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Aspirin experiment

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Limestone weathering

Decomposition reactions | 11–14 years

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More Resources

Student risk assessment: preparing a salt | 14–16 years

Structure and bonding: exploding exam questions | 14–16 years

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