How do scientists grow protein crystals? | 14-16 years

A 3D rendered model showing the structure of an oestrogen receptor molecule.

Source: © Shutterstock

Discover the methods and conditions used by chemical scientists to grow protein crystals in this lesson plan with activities for 14–16 year olds.

In this activity, students read and enact an interview with a protein chemist as a stimulus for applying their knowledge about growing crystals. Students then discuss issues arising from this in groups, with the objectives of being able to explain:

  • That proteins can form crystals.
  • The conditions under which protein crystals grow.
  • That crystal structures can be determined using X-ray crystallography.
  • Why protein crystals are investigated.

Thanks for using the RSC’s education resources. You can view one resource per month as a visitor, or two resources per month when you’re logged in with a personal account.

A photograph of a teacher standing in a white lab coat, speaking with a class of children in a laboratory, is superimposed on a colourful background. Text reads "Teach Chemistry means support for classroom and staff room".

Register for Teach Chemistry for free, unlimited access

Registration is open to all teachers and technicians at secondary schools, colleges and teacher training institutions in the UK and Ireland.

Get all this, plus much more: 

  • unlimited access to resources, core practical videos and Education in Chemistry articles
  • teacher well-being toolkit, personal development resources and online assessments
  • applications for funding to support your lessons

Already a Teach Chemistry member? Sign in now.

Not a science teacher or technician based in the UK or Ireland? Don’t worry – you can also access all our resources with Royal Society of Chemistry membership.