All Medicinal chemistry articles – Page 6

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    On This Day - Oct 19 : Samuel Guthrie died

    He discovered chloroform (trichloromethane) by distilling chloride of lime (a mixture of calcium hydroxide, chloride and hypochlorite) with alcohol in a copper barrel. He found that this had properties that made it a mild anaesthetic, which he used in amputations.

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    On This Day - Oct 15 : First contraceptive pill

    The pill was a steroid hormone, norethindrone, developed by Carl Djerassi and co-workers at Syntex in Mexico City. Around 100 million women worldwide now take contraceptive pills, which are approximately 99% effective against pregnancy.

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    On This Day - Oct 03 : Charles Pedersen was born

    He shared the 1987 Nobel Prize in Chemistry for the synthesis of crown ethers. These are a group of compounds that can “recognize” each other and choose which other molecules to form complexes, much like the behaviour of molecules found in living organisms.

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    On This Day - Oct 01 : Thalidomide was marketed

    This notorious drug was marketed as a mild sleeping pill that was safe even for pregnant women. It wasn’t until 1962 that the severe side effects were revealed, where it had caused the development of malformed limbs in babies.

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    On This Day - Jan 11 : Thompson trialled insulin

    On the verge of death, the 14 year old diabetic agreed to the trial. Insulin was first discovered by Banting, Best and Macleod in 1921, but it was Collip’s work on the purification of insulin that enabled it to be used clinically.

  • A tetrahedral molecule with two lone pairs
    The Mole

    The shapes of molecules

    2012-03-01T16:55:00Z

    Avogadro’s lab: Investigating why molecules have different shapes

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    Soundbite

    Vancomycin

    2012-03-01T00:00:00Z

    Simon Cotton takes a look at those compounds that find themselves in the news or relate to our everyday lives.

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    Feature

    Ruthenium compounds as anticancer agents

    2012-01-01T00:00:00Z

    New ruthenium-based compounds with fewer and less severe side effects, could replace longstanding platinum-based anticancer drugs

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    The Mole

    Can chemistry help you to forget?

    2011-11-01T16:29:00Z

    On screen chemistry with Jonathan Hare

  • William Roentgen, who discovered x-rays
    Feature

    Radium - a key element in early cancer treatment

    2011-03-01T00:00:00Z

    An early example of how blue skies research by Pierre and Marie Curie led to the treatment of previously incurable cancers

  • Gin and tonic
    The Mole

    Quinine

    2010-11-01T09:48:00Z

    Quinine was the first successful anti-malarial, but it is now more familiar to us as the bitter taste in tonic water, but what is the story?

  • Mars bar
    The Mole

    Chocolate

    2010-07-01T14:43:00Z

    That’s chemistry: The molecules behind Mars bars

  • Tomorrow's vaccines - designed and made in the lab
    Feature

    Synthetic vaccines

    2010-05-01T00:00:00Z

    The design of synthetic vaccines offers a more systematic approach to vaccine therapy for many illnesses, including cancer, and even drug addiction

  • A sailor using a telescope
    The Mole

    Lost at sea: could you find your way using alchemy?

    2010-01-01T00:00:00Z

    On screen chemistry with Jonathan Hare

  • Joseph Lister
    Feature

    Solving an infectious problem

    2009-09-01T00:00:00Z

    Joseph Lister's use of phenol as an antiseptic revolutionised surgical practice in the 19th century. But was he the first to use this antiseptic technique?

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    Feature

    Catalysts for a green industry

    2009-07-01T00:00:00Z

    Chemists are working to develop new, longer-lasting catalysts to ensure industrial processes are cleaner, greener and more efficient

  • Kew's greenhouse
    The Mole

    Kew the celebrations

    2009-05-01T07:24:00Z

    The Royal Botanic Gardens, Kew, celebrates 250 years of horticulture and science.

  • Electrical discharges from the nerve cells in the brain
    Feature

    Epilepsy - beyond bromide

    2009-05-01T00:00:00Z

    An historical journey into the treatment of epilepsy, starting with potassium bromide 150 years ago

  • Feet on weighing scales
    The Mole

    Obesity – at what cost

    2009-03-01T07:16:00Z

    Do drugs have a part to play in controlling obesity?

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    The Mole

    Antimalarial drugs

    2009-01-01T14:56:00Z

    Approximately one million people die annually from malaria worldwide. Tragically, 90 per cent of these deaths are among the under-fives in sub-Saharan Africa, who have little if any access to adequate healthcare. Drugs are used to treat the disease but parasitic resistance to these drugs is growing, so what is the alternative?